Dr. Mamatha Serasanambati, Ph.D.

Dr. Serasanambati hails from India and obtained a Ph.D. in her home country. Her research interests encompass various areas, such as cancer biology, genetic disorders, and translational medicine. Presently, she is engaged in investigating the AXL pathway within melanoma and immune cells, specifically in relation to treatment and disease progression. Furthermore, she is placing emphasis on utilizing organoids for Personalized Immunotherapy in Melanoma.

This involves characterizing the molecular and genetic profile of the organoids, assessing the efficacy of immunotherapies like checkpoint inhibitors on the organoids in vitro, and identifying biomarkers linked to organoid responses to immunotherapy. In Dr. Serasanambati’s leisure time, she enjoys music, cooking, and spending quality time with her family.

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Publications

• Book Chapter

1. Wu Y, Terekhanova NV, Caravan W, Naser Al Deen N, Lal P, Chen S, Mo CK, Cao S, Li Y, Karpova A, Liu R, Zhao Y, Shinkle A, Strunilin I, Weimholt C, Sato K, Yao L, Serasanambati M, etc, “Epigenetic and Transcriptomic Characterization Reveals Progression Markers and Essential Pathways in Clear Cell Renal Cell Carcinoma”, Nature Communication 2023 Mar 27;14(1):1681.

2. Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo CK, Liu J, Southard-Smith AN, Wu Y, Naser Al Deen N, Baer JM, Fulton RS, Wyczalkowski MA, Liu R, Fronick CC, Fulton LA, Shinkle A, Thammavong L, Zhu H, Sun H, Wang LB, Li Y, Zuo C, McMichael JF, Davies SR, Appelbaum EL, Robbins KJ, Chasnoff SE, Yang X, Reeb AN, Oh C, Serasanambati M, etc, “Spatially Restricted Drivers and Transitional Cell Populations Cooperate With the Microenvironment in Untreated and Chemo-Resistant Pancreatic Cancer”, Nature genetics, 2022 Aug 22.

3. Yige Wu, Nadezhda Terekhanova, Wagma Caravan, Alla Karpova, Song Cao, Siqi Chen, Houxiang Zhu, Preet Lal, Mamatha Serasanambati, etc, “Chromatin accessibility shapes tumor architecture and microenvironment in clear cell renal cell carcinoma”, Submitted to Research Square, 2022. https://doi.org/10.21203/rs.3.rs-229922/v1.

4. Mamatha Serasanambati, Yoav Y. Broza, Hossam Haick. Cell‐ Cell Cross Talk: Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation. Adv. Biosys. 2019, 3 (10). Selected as a cover image in Advanced Bio-systems Journal.

5. Mamatha Serasanambati, Yoav Y. Broza, Abraham Marmur, Hossam Haick. Profiling Single Cancer Cells with Volatolomics Approach. iScience 2019, 11, 178-188. Selected as a cover image in iScience Journal.

6. Mamatha Serasanambati*, Shanmuga Reddy Chilakapati. Function of Nuclear Factor kappa B (NF-kB) in human diseases -A Review. South Indian Journal of Biological Sciences 2016; 2(4); 368-387.

7. Mamatha Serasanambati, Shanmuga C. Reddy, Pavan Kumar Manikonda, Jagadeeswara Reddy Kanala. Anticancer activity of methanolic extract of Berberis aristata in MCF -7 human breast cancer cell lines. Int. J. LifeSc. Bt & Pharm. Res. 2015; 4, (1).

8. Mamatha Serasanambati, Shanmuga C. Reddy, Jhansi Rani Vangavaragu, Damodar Reddy Chilakapati. Inhibitory effect of gemcitabine and brucine on MDA MB- 231human breast cancer cells. Int. J. Drug. Deliv. 2014; 6(2).

9. Mamatha Serasanambati, Shanmuga C. Reddy, Pavan Kumar Manikonda, Jagadeeswara Reddy Kanala, Damodar Reddy Chilakapati. Anti-cancer effects of brucine and gemcitabine combination in MCF -7 human breast cancer cells. Nat. Prod. Res. 2014; 28:1-7.

10. Mamatha Serasanambati, Shanmuga C. Reddy, Jagadeeswara Reddy Kanala, Damodar Reddy. Gemcitabine and brucine inhibit MDA MB-436 human breast cancer cells. Sch. Acad. J. Biosci. 2014; 2:71-75.

11. Mamatha Serasanambati, Shanmuga C. Reddy, Pavan Kumar Manikonda and Jagadeeswara Reddy Kanala. Curcumin potentiates antitumor effect of gemcitabine in human breast cancer in vitro. Current Trends in Biotechnology and Pharmacy 2013; 7:854-861.

12. Mamatha Reddy Serasanambati, Krishna Kumari Challa, Shanmuga C. Reddy, Raja Ratna Reddy Yakkanti, Damodar Reddy Chilakapati. Antimicrobial activity of leaf extracts of Sida cordifolia. IRJP. 2012; 3:309-311.

13. Shanmuga C. Reddy, Mamatha Serasanambati, Pavan Kumar Manikonda, Jagadeeswara Reddy Kanala. Dietary lutein attenuates bleomycin induced pulmonary fi brosis. Int. J.Durg Deliv. 2014; 6; 380-388.

14. Shanmuga C. Reddy, Mamatha Serasanambati, PrabhkarVissavajjhala, Jagadeeshwara Reddy Kanala, Damodar Reddy. Amelioration of bleomycin induced pulmonary fibrosis ina mouse model by a combination therapy of Bosentan and Imatinib. Exp. Lung. Res. 2015; 41:173 -188.

15. Shanmuga C. Reddy, Mamatha Serasanambati, Damodar Reddy, Pavan Kumar Manikonda, Ronald Ross Watson. Oral administrat ion of Passion Fruit Peel Extract attenuates the bleomycin induced pulmonary fibrosis in mice. Can. J. Physiol. Pharmacol. 2014; 92:631 -639.

16. Shanmuga C. Reddy, Mamatha Serasanambati, Jagadeeshwara Reddy Kanala, Pavan Kumar Manikonda, D amodar Reddy. Oral administration of bosentan attenuates the bleomycin induced pulmonary fibrosis in mice. Int. J. Life Sc. Bt & Pharm. Res. 2014; 3(2).

17. Raja Ratna Reddy Yakkanti, Krishna Kumari Challa, Lokanatha Oruganti, Mamatha Serasanambati, Damodar Reddy Chilakapati. Antimicrobial activity of Azadirachta Indica (neem) leaf, bark and seed extracts. Int. J. of Res. Phytoche and Pharma, 2013; 3:1 -4.