Dr. Saurabh Sharma, Ph.D.

Dr. Sharma’s current endeavor is focused on addressing the critical need for effective therapies in CNS metastases of melanoma, an area in which modern systemic therapy has made minimal progress with patients continuing to show extremely poor outcomes in checkpoint refractory disease. Dr. Sharma has shown an aptitude for meticulous drug development and has rapidly developed important skills in the unique modeling of the metastatic tumor environment. Recently, Saurabh's application was accepted to the SITC Sparkathon-2023 in prestigious program for promising early investigators to develop high priority immunotherapy projects under direct mentorship of society leaders for development of brain nano targeted immunotherapy.

Recently he has applied for the 2023 Society for Immunotherapy of Cancer (SITC) Bristol Myers Cancer Immunotherapy Translational Fellowship Award. Prior to joining the Prof. Amanda R. Kirane (Director of cutaneous melanoma surgery) at Surgery Department, Stanford School of Medicine, Stanford university, Dr. Sharma got the opportunity to work on novel immuno-nanoconjugates for brain cancer (Glioblastoma) as a Postdoctoral Chemist and Pharmacologist under the mentorship of Prof. Ali Khademhosseini (Biomaterial, Tissue Engineering Pioneer, EX-MIT and EX-UCLA Professor and Current CEO, Terasaki Institute) and Prof. Eggehard Holler (EX-Director of Nanomedicine, Cedar Sinai Medical Research Center, Los Angeles, California) at Terasaki Institute for Biomedical Innovation, Los Angeles, California, USA.

He worked as an assistant Professor at Department of Pharmaceutical Sciences, School of Health Sciences, UPES Dehradun, India. He pursued his Ph.D (Doctoral Degree) from BITS-Pilani, Pilani Campus, Rajasthan, India. During the PhD research work, Dr. Sharma has designed & developed the novel drug delivery systems for the delivery of the genetic materials (e.g., miRNA, siRNA) and chemotherapeutic agents.

The research has a significant contribution in the field of developing novel treatment strategies for cancer therapy. He has experienced significant success in his early career, prior to joining post-doctoral program, as evidenced by his guest Speaker in VIT, Parul University and International Virtual Conference on Recent Trends in Life Sciences. He received a Council of Scientific & Industrial Research (CSIR-SRF) Senior Research Fellowship Award and several presentation awards at various International conferences. Further in detail, Dr. Sharma has shown significant success and contribution in his field as evident by: Dr Sharma holds two granted patents one US patent, PCT and other Indian patent in the field of developing novel drug delivery systems. Dr. Sharma published more than 24 publications (Since 2018, Citations:218, h-Index:10, I10-Index:10) his work at Internationally reputed high-Impact factor journal which included: Advance Science, Small, Lab On a Chip, Acta Biomaterialia, Biomaterials Advances (Materials Science and Engineering: C), Nanomedicine: Nanotechnology, Biology and Medicine, Regenerative Biomaterials, Applied Surface Science, Molecular pharmaceutics, International Journal of Pharmaceutics etc several others.

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Achievements

I have been accepted into Sparkathon 2023. The program, sponsored by the Society for Immunotherapy of Cancer, brings together early career scientists for several meetings over the course of the year including an in-person retreat on September 27-29, 2023 in Chicago, IL, and the one-day symposium prior to SITC’s 38th Annual Meeting and Pre-Conference Programs on November 1, 2023 in San Diego, CA. This year’s topic is “TOXICITIES IN CANCER IMMUNOTHERAPY.” I recently presented “Blood Brain Barrier Directed Immunotherapy Nano-conjugates for Checkpoint-refractory Melanoma Brain Metastasis” at Stanford’s annual Holman Day.

Publications

Total: 26 Publication, Citations: 238, H index: 10, i10 index: 11

Google Scholar Link: https://scholar.google.co.in/citations?hl=en&user=AETtSwIAAAAJ&view_op=list_works&sortby=pubdate

Selected Publication:

• Saurabh Sharma, Sudeep Sudesh Pukale, Deepak K. Sahel, Prabhjeet Singh, Manu Dalela, Sujata Mohanty, Anupama Mittal, Deepak Chitkara. "Folate targeted hybrid lipo-polymeric nanoplexes containing docetaxel and miRNA-34a for breast cancer treatment". Biomaterials Advances (Formerly knows as: Materials Science and Engineering: C) (2021). IF: 8.45

• Saurabh Sharma, Samrat Mazumdar, Kishan S. Italiya, Tushar Date, Ram I. Mahato, Anupama Mittal, and Deepak Chitkara. "Cholesterol and Morpholine grafted cationic Amphiphilic copolymers for miRNA-34a delivery." Molecular pharmaceutics, ACS, 15, no. 6 (2018). IF: 5.36

• Saurabh Sharma, Sudeep Sudesh Pukale, Deepak K. Sahel, Devesh S. Agarwal, Manu Dalela, Sujata Mohanty, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkara. “Folate targeted cholesterol-grafted lipo-polymeric nanoparticles for chemotherapeutic agent delivery.” Springer, AAPS PharmSciTech (2020), IF: 5.36

• Saurabh Sharma, Sudeep S. Pukale, Anupama Mittal, Deepak Chitkara. “Docetaxel and its nanoformulations: how delivery strategies could impact the therapeutic outcome?” Therapeutic delivery (2020).

• Saurabh Sharma, Kishan Italiya, Anupama Mittal, and Deepak Chitkara. "New strategies for cancer management: how can temozolomide carrier modifications improve its delivery? Future Science, Therapeutic delivery (2017): 475-477.

• Sudeep S. Pukale, Saurabh Sharma, Arihant K Singh, Manu Dalela; Arihant K Singh; Sujata Mohanty; Anupama Mittal Deepak Chitkara. “Multi-component clobetasol-loaded monolithic lipid- polymer hybrid nanoparticles ameliorates imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice.” Acta Biomaterialia (2020), IF: 10.63

• Deepak Kumar Sahel, Lalitkumar K Vora, Aishwarya Saraswat, Saurabh Sharma, Jasmin Monpara , Anisha A D'Souza , Satoru Kawakita , Shahid khan, Ketan Patel, Deepakkumar Mishra , Dharmendra Khatri, Raghu Raj Singh Thakur. “CRISPR/Cas9 genome editing for tissue-specific in vivo targeting: Nanomaterials and translational perspective” Advance Science 2023, IF: 16.80

• Satoru Kawakita, Kalpana Mandal, Lei Mou, Marvin Mecwan, Yangzhi Zhu, Shaopei Li, Saurabh Sharma, Ana Lopez Hernandez, Natan, Barros, Surjendu Maity, Praveen Bandaru, Aya Nakayama, Samad Ahadian, Han-Jun Kim, Rondinelli Donizetti Herculano, Eggehard Holler, Vadim Jucaud, Mehmet Remzi Dokmeci*, Ali Khademhosseini*. Organ-on-a-Chip Models of the Blood-Brain Barrier for Drug Discovery and Personalized Medicine. Small (Wiley). 2022. IF: 15.15